The Mental Health Commission of Canada (MHCC) is funding 14 community-based research projects (2020–22) to explore the relationship between cannabis and mental health in diverse populations. These initiatives focus on priority groups such as marginalized communities, Indigenous peoples, youth, older adults, and justice-involved individuals. Key projects include stigma reduction via participatory videos, analyzing the effects of cannabis legalization on at-risk populations, and creating tools for healthcare providers. Indigenous-led projects emphasize cultural perspectives, harm reduction, and traditional knowledge, while others address unique needs of 2SLGBTQ+ youth, mothers, and seniors. These studies aim to inform policy, reduce stigma, and foster mental wellness through evidence-based approaches.